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Pyrazines and learned behaviour

( help to cause nicotine addiction)

Pyrazine stimulation of olfactory receptors may enhance learned behaviour, either by acting alone or in combination with other sensory modality stimuli.90 ,91 Human responses to chemosensory and olfactory effects that are associated with emotionally significant experiences can become constitutional through neuroplastic changes in the olfactory pathways to the limbic system as well as other areas of the brain associated with hedonic perception.92 ,93 Such events can reinforce smoking through associative learning and become cues for increased hedonic valence of stimuli94 and motivate increased desire or wanting, or even unrestrained consumption.

Ref:

https://tobaccocontrol.bmj.com/content/25/4/444

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